摘要
目的:了解我院药品不良反应(ADR)发生情况及特点,为临床合理用药提供参考。方法对我院2011年~2012年收集的445例ADR报告,通过 EXCEL软件分别从患者性别、年龄、剂型、给药途径、药品种类、合并用药、报告类型、转归、报告人职业、药品类别以及累及器官或系统及临床表现等方面进行回顾性统计和分析。结果 ADR发生男、女比例为1.13:1;患者(18~59岁)ADR发生率最高(239例,53.7%);静脉滴注引发ADR最多,共337例(75.7%);共有206个品种引起不良反应,涉及药物以抗感染药居多(40.2%),头孢菌素类抗生素引起73例(40.8%);其次为中药制剂;ADR 最为常见的临床表现为皮肤及附件损害(47.9%)。结论应重视和加强ADR的监测,减少甚至避免ADR的发生。
Objective To investigate the occurrence of adverse drug reaction(ADR)in our hospital for reference of rationa1 use of drugs.Methods 445 ADR cases reported by our hospital from 2011 to 2012 were Retrospective analyzed statistical y in terms of gender,age,dosage form,administration route,drug types,drug combination,report types,prognosis,reports occupation,systems or organs involved in ADR and clinical manifestations by excel,etc.Results Male to female ratio was1.13:1;239cases were between 18 to 59 years old(53.7%);337 cases were induced by intravenous infusion(75.7%);206drug types cause ADRs,40.2%of case were mainly caused by antibiotics;73 cases were caused by cephalosporins(40.8%),fol owed by traditional chinese medicine;main clinical manifestations of ADR were lesion of skin and appendants,accounting for 47.9%.Conclusion We should pay at ention to ADR monitoring,rational use of antibiotics in order to reduce and avoid the incidence of ADR.
作者
李金卓
刘燕飞
LI Jin-zhuo;LIU Yan-fei(Guangxi Hezhou City People's Hospital Department of Pharmacy,Hezhou Guangxi 542800,China)
关键词
药品不良反应
报告
分析
Adverse drug reaction
Reports
Analysis