摘要
Objective:To investigate the frequency of deficiency of spleen qi (DSQ) in persons with Parkinson disease (PD) as well as the correlation between DSQ and PD.Methods:This study comprised three parts:determining the frequency of DSQ in participants with PD;comparing the frequency of DSQin PD and non-PD participants;and monitoring DSQ in participants with PD for 24 weeks.Outcome measurements were a modified DSQ scale and the Chinese version of the Parkinson Disease Questionnaire 39 (C-PDQ39).Results:A total of 187 participants with PD (mean ages 69.9 ± 9.6 years) completed the assessment in Part 1.Of these,170 (90.9%) were diagnosed as having DSQ.Thirty non-PD participants (mean ages 66.6 ± 10.2 years) completed the assessment in Part 2.Of these 11 (36.7%) were diagnosed as having DSQ.Positive correlations between total DSQ score and Hoehn-and-Yahr (H&Y) stage (correlation 0.316;P <.001),as well as between DSQ and total C-PDQ39 score (correlation 0.572;P <.001),were observed.For Part 3,47 participants from Part 1 were observed for 24 weeks.Variation in DSQ symptoms was noted,but all participants developed DSQ by the end of the study.Conclusions:DSQ is 2.5 times higher in PD participants than in the non-PD participants.More PD participants had DSQ in the advanced H&Y stages.A larger study is needed to validate these results on the prevalence of DSQ in persons with PD.
