痛性糖尿病周围神经病变患者血清神经元特异性烯醇化酶与疼痛的相关性研究

Correlation between serum neuron-specific enolase and pain degree in patients with painful diabetic peripheral neuropathy

目的 探讨痛性糖尿病周围神经病变(PDPN)患者血清神经元特异性烯醇化酶(NSE)与疼痛的相关性.方法 选择2012年1月至2017年5月就诊于连云港市第二人民医院老年医学科的PDPN患者70例为PDPN组,另有非痛性DPN患者70例为DPN组.PDPN组给予单唾液酸四己糖神经节苷脂钠40 mg溶于生理盐水250 ml中静脉滴注,1次/d,同时口服羟苯磺酸钙分散片0.5 g,2次/d,共2周.DPN组给予甲钴胺注射液0.5 mg,静脉注射,1次/d,治疗2周.分别于治疗前及治疗开始后1周、2周、8周时对受试者做VAS评估并测量血清NSE水平.结果 (1) PDPN组血清NSE水平高于DPN组[(16.9±6.6)vs.(10.2±4.4)μg/L](P<0.05);(2)不同疼痛部位的血清NSE值差异无统计学意义(p>0.05);(3)与治疗前比较,PDPN组治疗开始后1、2、8周VAS评分及NSE值均逐渐降低,差异有统计学意义(P<0.05);(4)血清NSE值与VAS评分呈正相关(R=0.801,P<0.05).结论 PDPN患者血清NSE水平与疼痛程度呈正相关.

Objective To investigate the correlation between serum neuron-specific enolase(NSE)and pain degree in patients with painful diabetic peripheral neuropathy(PDPN).Methods Seventy patients with PDPN hospitalized from January 2012 to May 2017 in the Department of Geriatrics,Lianyungang Second Hospital were selected as the PDPN group,and seventy patients with non-painful DPN were selected as the DPN group.Patients were given monosialotetrahexosyl ganglioside sodium 40 mg dissolved in normal saline 250 ml intravenously once a day,and oral calcium dobesilate 0.5 g,twice per day in PDPN group.While patients were treated with methylcobalamin intravenous injection 0.5 mg per day for two weeks in the DPN group.VAS and serum NSE were evaluated before the treatment,and at 1 week,2 weeks and 8 weeks of the treatment.Results(1)The serum level of NSE was significantly higher in PDPN group than that in DPN group[(16.9±6.6)vs.(10.2±4.4)μg/L](P<0.05).(2)There was no significant difference in serum NSE among different painful body parts(P>0.05).(3)Compared with pre-treatment,VAS and NSE were significantly and gradually decreased at 1,2 and 8 weeks of the treatment(P<0.05).(4)There was a positive correlation between serum NSE value and VAS(R=0.801,P<0.05).Conclusion There is a positive correlation between the serum level of NSE and the degree of pain in patients with PDPN.