摘要
Objective: To study the correlation between serum vitamin D levels with glycolipid metabolism, inflammatory factors secretion in pregnant women with gestational diabetes mellitus(GDM). Methods: GDM pregnant women diagnosed in our hospital from March 2015 to February 2018 were selected as GDM group, and healthy pregnant women who underwent obstetric examination and delivered at the same time were selected as control group. Fasting venous blood was collected at 24 weeks of gestation and 25 (OH) D3, glucose and lipid metabolism indexes, inflammatory factors were measured. The placenta tissues after delivery were collected and the mRNA expression of biological signal molecules was measured. Results: Serum 25 (OH) D3, HDL-C, apoA1/apoB, APN, Omentin-1 and mRNA expression of GLUT3, GLUT4, IRS-1 in placenta of GDM group were significantly lower than those in control group, serum F-INS, HOMA-IR, LDL-C, IL-6, TNF-a and the mRNA expressions of TLR4, NF-κB in placenta were significantly higher than those in control group. Serum 25 (OH) D3 of GDM group was positively correlated with serum HDL-C, apoA1/apoB, APN, Omentin-1 and mRNA expression of GLUT3, GLUT4, IRS-1 in placenta, whereas negatively correlated with serum F-INS, HOMA-IR, LDL-C, IL-6, TNF-a and the mRNA expressions of TLR4, NF-κB in placenta. Conclusion: The decrease of serum vitamin D level in GDM pregnant women closely correlates with the disorder of glucose and lipid metabolism and abnormal secretion of inflammatory factors.
