摘要
Objective:To study the relationship of smoking with periodontal tissue inflammation and alveolar bone resorption in patients with chronic periodontitis.Methods: The patients diagnosed with periodontitis in Yingkou Central Hospital between March 2015 and March 2017 were selected and divided into the periodontitis group A with smoking history and the periodontitis group B without smoking history;volunteers who received physical examination in Yingkou Central Hospital during the same period and were without history of periodontitis or smoking were collected as the control group. The gingival crevicular fluid was collected to measure the contents of inflammation indexes and alveolar bone resorption indexes.Results:ICAM1, HMGB1, IL-17, YKL40, CXCL16, NTX, CTX, RANKL, MMP9 and EA contents in gingival crevicular fluid of periodontitis group A and periodontitis group B were significantly higher than those of control group while PICP, PIIICP, OPG and Runx2 contents were significantly lower than those of control group;ICAM1, HMGB1, IL-17, YKL40, CXCL16, NTX, CTX, RANKL, MMP9 and EA contents in gingival crevicular fluid of periodontitis group A were significantly higher than periodontitis group B while PICP, PIIICP, OPG and Runx2 contents were significantly lower than those of periodontitis group B.Conclusion:Smoking can aggravate the periodontal tissue inflammation and promote the alveolar bone resorption in patients with chronic periodontitis.
