摘要
Objective:To investigate the effects of Huachansu capsules combined with raltitrexed and olisaplatin on advanced colorectal cancer immunity, tumor markers, matrix metalloproteinases and angiogenesis.Methods: Eighty-two patients with advanced colorectal cancer who were treated in our hospital from August 2015 to September 2017 were randomly divided into the control group (41 cases) and the observation group (41 cases), the control group was treated with raltitrex plus oxaliplatin, on the basis of the control group, the observation group was treated with Huachansu Capsule. The levels of immune function, tumor markers, matrix metalloproteinases and angiogenic factors were compared before and after treatment in two groups of patients with advanced colorectal cancer.Results: After treatment, the levels of CD4+ and CD4+/CD8+ in the two groups were significantly higher than those before treatment (P<0.05), and the levels of CD4+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group (P<0.05). the levels of CA125, CA19-9 and CEA in the two groups were significantly lower than those before treatment (P<0.05), and the levels of CA125, CA19-9 and CEA in the observation group were significantly lower than those in the control group (P<0.05);the levels of MMP-2 and MMP-9 in the two groups were significantly lower than those before treatment (P<0.05), and the levels of MMP-2 and MMP-9 in the observation group were significantly lower than those in the control group (P<0.05);the levels of VEGF, HIF-1α and TGF-β1 in the two groups were significantly lower than those before treatment (P<0.05), and the levels of VEGF, HIF-1α and TGF-β1 in the observation group were significantly lower than those in the control group (P<0.05).Conclusions: Huachansu Capsule combined with retidoxed and olixaplatin chemotherapy regimen can enhance the immune function of patients with advanced colorectal cancer, reduce the level of tumor markers in serum, inhibit the growth and metastasis of tumor cells and angiogenesis, which has clinical significance.
