摘要
Objective:To detect serum content of calcitonin gene-related peptide (CGRP) in patients with reflux esophagitis (RE), evaluate the relationship between CGRP and gastrointestinal hormones, inflammatory response.Methods: 119 cases of RE patients diagnosed in our hospital during August 2015 to March 2018 were divided into stage I-II RE group (n=72) and stage III-IV RE group (n=47) according to Savary-Miller criteria, 100 cases of healthy volunteers underwent routine gastroenteroscopy at the same time were selected as Normal control group. Serum content of CGRP, gastrointestinal hormones and inflammatory response indexes were measured and their correlations were evaluated.Results: Serum content of CGRP in stage I-II RE group, stage III-IV RE group were higher than those in Normal control group;contents of GAS and MTL in stage I-II RE group, stage III-IV RE group were lower than those in Normal control group, contents of VIP and SS were higher than those in Normal control group;contents of inflammatory reaction indexes such as IL-4, IL-17, IL-23 and IFN-γwere higher than those in Normal control group (P<0.05). Along with aggravation of RE, above indexes increased significantly (P<0.05). Correlation analysis showed that, serum content of CGRP in RE patients were directly related to the levels of gastrointestinal hormones and inflammatory markers (P<0.05).Conclusion: Expression of CGRP in RE patients is abnormally high, and the specific content is directly related to the degree of gastrointestinal hormone secretion disorder and systemic inflammatory reaction, which is of great significance to the auxiliary evaluation of RE.
