摘要
Objective:To investigate the changes of serum carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), lactate dehydrogenase (LDH) andβ2-microglobulin (β2-MG) in patients with malignant lymphoma.Methods: A total of 71 patients with malignant lymphoma treated in our hospital from April 2015 to April 2017 were selected. All patients were treated with first-line chemotherapy CHOP, with 28 d as the 1 cycle and continuous chemotherapy for 4 cycles. CEA andβ2-MG were detected by fluorescence immunoassay, CA125 by enzyme-linked immunosorbent assay and LHD by rate method. The changes of serum CEA, CA125, LDH andβ2-MG levels were compared in patients with different stages, different curative effects and 1-year survival and death.Results: The levels of serum CEA, CA125, LDH andβ2-MG in stage III-IV were higher than those in stage I-II. The levels of serum CEA, CA125, LDH andβ2-MG in the ineffective patients were significantly higher than those in the effective patients. The levels of serum CEA, CA125, LDH andβ2-MG in the death group were higher than those in the survival group.Conclusion: The serum levels of CEA, CA125, LDH andβ2-MG in patients with malignant lymphoma increase with the increase of clinical stages and poor prognosis, which can be used as an effective indicator for the condition, treatment and prognosis of patients with malignant lymphoma.
