摘要
Objective: To study the correlation of serum trace element changes with inflammatory cytokines and oxidative stress indexes in patients with urinary tract infection (UTI). Methods: The patients who were diagnosed with lower urinary tract infection in our hospital between March 2013 and December 2017 were selected as the UTI group and the healthy volunteers who received physical examination were selected as the control group. Serum was collected to measure the contents of trace elements and inflammatory cytokines, and urine was collected to measure the contents of oxidative stress indexes. Results: The content of Zinc (Zn) in serum of the UTI group was significantly lower than that of the control group (P<0.05) while the contents of Copper (Cu), Selenium (Se), Calcium (Ca) and Magnesium (Mg) were not significantly different from those of the control group (P>0.05);the contents of C-reactive protein (CRP), amyloid protein A (SAA), procalcitonin (PCT), intercellular adhesion molecule-1 (ICAM-1), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-5(IL-5), interleukin-17(IL-17) and transforming growth factor-β1 (TGF-β1) in serum as well as the contents of malondialdehyde (MDA) and advanced oxidation protein product (AOPP) in urine of the UTI group were significantly higher than those of the control group and negatively correlated with the content of Zn in serum (r=-0.514, -0.573, -0.475, -0.636, -0.612, -0.585,-0.492, -0.537, -0.611, -0.476 and -0.542, p=0.015, 0.011, 0.024, 0.007, 0.009, 0.010, 0.020, 0.014, 0.009, 0.024 and 0.013) while the contents of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in urine were significantly lower than those of the control group and positively correlated with the content of Zn in serum (r=0.592, 0.657 and 0.610, p=0.010, 0.002 and 0.009). Conclusion: Serum trace element Zn significantly decreases in patients with urinary tract infection and it is closely related to the occurrence of disease as well as the abnormality of inflammation, immune response and oxidative stress in the course of the disease.
