摘要
Objective:To investigate the difference between constant infusion of dexmedetomidine and target-controlled infusion of remifentanil in the laparoscopic operation of children with inguinal hernia.Methods: A total of 80 children with inguinal hernia who underwent laparoscopic surgery in the hospital between September 2016 and December 2017 were selected as the research subjects and randomly divided into dexmedetomidine (group D) (n=40) and remifentanil group (group R) (n=40). Group D received constant intravenous infusion of dexmedetomidine after anesthesia induction, group R received constant infusion of same volume of saline after anesthesia induction, and the propofol and remifentanil were stopped at 2 min before the operation ended. The differences in hemodynamic index levels as well as serum contents of inflammatory factors and neuroendocrine indicators immediately after extubation (T0), 5 min after extubation (T1) and 10 min after extubation (T2) were compared between the two groups of children.Results: At T0, hemodynamic index levels as well as serum contents of inflammatory factors and neuroendocrine indexes were not significantly different between the two groups. At T1 and T2, hemodynamic indexes MAP and HR levels of group D were lower than those of group R;serum inflammatory factors IL-1β, IL-6 and CRP contents were lower than those of group R;neuroendocrine indicators Cor, NE, FT4 and Ang-Ⅱ contents were lower than those of group R.Conclusion: Constant infusion of dexmedetomidine can effectively relieve the postoperative hemodynamic fluctuation, and inhibit the inflammatory response and stress response in children with inguinal hernia.
