摘要
Objective:To study the curative effect and prognosis of endoscopic tissue glue + lauromacrogol therapy for patients with cirrhosis and variceal bleeding.Methods: Patients with cirrhosis and variceal bleeding who underwent endoscopic hemostasis in the First Hospital of Yulin between March 2015 and February 2018 were retrospectively studied and divided into the observation group who accepted endoscopic hemostasis by lauromacrogol - tissue glue - lauromacrogol solution and the control group who accepted endoscopic hemostasis by lipiodol - tissue glue - lipiodol solution according to the history data. After treatment, the hemostasis time was observed, and the differences in blood routine indicators, stress-related hormones, oxidation-related mediators and inflammation-related mediators were compared.Results: The mean hemostasis time of observation group was shorter than that of control group, hemoglobin and hematokrit after 24 h of treatment were higher than those of control group, and serum GAS, AT-II, NE, E, Cor, MDA, LPO, NO, iNOS, p38MAPK, NF-κB, TNF-α, IL-6 and IL-8 levels were lower than those of control group.Conclusion: Endoscopic tissue glue combined with lauromacrogol therapy is better than tissue glue combined with lipiodol therapy in hemostasis, and can also relieve the oxidative stress response and inflammatory response.
