摘要
Objective:To study the correlation of Vav1 and cathepsin D (CTSD) expression with the clinical biological behaviors in endoscopic biopsy gastric cancer tissue.Methods: Patients who were diagnosed with gastric cancer by gastroscopic biopsy in the 252 Hospital of PLA between April 2015 and December 2017 were selected, and the gastric cancer tissues and adjacent tissues from endoscopic biopsy were collected to determine the expression of Vav1, CTSD, invasion genes and proliferation genes.Results: Vav1, CTSD, HDAC5, Twist1, N-cadherin, MMP2, PTP1B, ATAD2, CyclinD1 and PCNA mRNA expression in gastric cancer tissues were significantly higher than those in adjacent tissues whereas BTG3, WTX, FAF1, Fas and Mxi1 mRNA expression were significantly lower than those in adjacent tissues;Vav1 and CTSD mRNA expression in gastric cancer tissues were positively correlated with HDAC5, Twist1, N-cadherin, MMP2, PTP1B, ATAD2, CyclinD1 and PCNA mRNA expression, and negatively correlated with BTG3, WTX, FAF1, Fas and Mxi1 mRNA expression.Conclusion:The high expression of Vav1 and CTSD in the endoscopic biopsy gastric cancer tissues is correlated with the invasion genes and proliferation genes that are related to the clinical biological behaviors of the tumor.
