摘要
Objective:To study the effect of nicorandil on postoperative myocardial injury, platelet function and inflammatory response in patients with slow reflow in PCI.Methods: Patients who underwent emergency PCI and had intraoperative slow reflow in Zigong Fourth People's Hospital between March 2015 and August 2017 were selected and divided into nicorandil group and normal control group according to the application of nicorandil after no reflow or not in the history data. The levels of myocardial injury indexes in serum as well as the expression of platelet activation molecules and inflammatory signaling molecules in peripheral blood were measured before PCI as well as 1 day and 3 days after PCI.Results: Compared with the corresponding indexes of same group before PCI, serum H-FABP, HIF-1α, CK-MB and cTnⅠlevels as well as peripheral blood PAR1, PAR4, CCR2, p38MAPK, HSP27, Notch1, NF-κB, MEK1, ERK1/2 and CaMKⅡ mRNA expression of both groups of patients were significantly lower 1 day and 3 days after PCI, and serum H-FABP, HIF-1α, CK-MB and cTnⅠ levels as well as peripheral blood PAR1, PAR4, CCR2, p38MAPK, HSP27, Notch1, NF-κB, MEK1, ERK1/2 and CaMKII mRNA expression of nicorandil group 1 day and 3 days after PCI were significantly lower than those of normal control group.Conclusions:Nicorandil has negative regulating effect on postoperative myocardial injury, platelet activation and inflammatory response activation in patients with slow reflow in PCI.
