摘要
Objective:To study the expression of TLR4 in peripheral blood mononuclear cells with myocardial injury and inflammatory stress response in patients with acute myocardial infarction.Methods:Patients who were diagnosed with acute myocardial infarction, unstable angina pectoris and stable angina pectoris in the People's Hospital of Huangmei between June 2014 and August 2017 were enrolled in the AMI group, UAP group and SAP group of the study respectively, and the volunteers who received physical examination in the People's Hospital of Huangmei during the same period were selected as the control group. The expression levels of TLR4 and stress indexes in peripheral blood mononuclear cells as well as the levels of myocardial injury indexes, inflammation indexes and stress indexes in serum were measured.Results:TLR4, Nrf2, NQO-1 andγ-GCS mRNA expression in peripheral blood mononuclear cells as well as CK, LDH, CK-MB, cTnT, MMP9, HMGB1, sVCAM1, IFN-γ, IL-17, MDA and AOPP levels in serum of AMI group were higher than those of UAP group, SAP group and control group;TLR4 mRNA expression in peripheral blood mononuclear cells of patients with AMI was positively correlated with CK, LDH, CK-MB, cTnT, MMP9, HMGB1, sVCAM1, IFN-γ, IL-17, MDA and AOPP levels in serum as well as Nrf2, NQO-1 andγ-GCS mRNA expression in peripheral blood.Conclusion:The high expression of TLR4 in peripheral blood mononuclear cells of patients with acute myocardial infarction can aggravate the myocardial injury and promote the activation of inflammatory stress response.
