摘要
Objective:To study the correlation of serum platelet activating factor (PAF) level with inflammatory response indexes and blood lipid metabolism in patients with posterior circulation cerebral infarction.Methods: Patients who were hospitalized and diagnosed with posterior circulation cerebral infarction in Neurology Department of Foshan Second People's Hospital between October 2016 and October 2017 were selected as the cerebral infarction group of the research, and healthy volunteers who received physical examination in the hospital during the same period were selected as control group. Serum was collected to determine the contents of PAF, inflammatory response indexes and lipid metabolism indexes.Results:Serum PAF, HMGB1, FKN, CD40L, IL-18, HCY, DKK1, LDL-C, Vaspin and Resistin levels of cerebral infarction group were greatly higher than those of control group whereas Visfatin level was greatly lower than that of control group;serum HMGB1, FKN, CD40L, IL-18, HCY, DKK1, LDL-C, Vaspin and Resistin levels of cerebral infarction group of patients with high PAF level were greatly higher than those of patients with low PAF level whereas Visfatin level was greatly lower than that of patients with low PAF level.Conclusion: The increase of PAF content in serum of patients with posterior circulation cerebral infarction is closely related to the inflammatory response activation and lipid metabolism disorder.
