摘要
Objective:To investigate the influence of TRPV1 and LGR5 on downstream proliferation and invasion-related gene expression in endocardial cancer lesions.Methods:A total of 40 patients with endometrial cancer undergoing surgical treatment in our hospital between June 2013 and June 2017 were selected, TRPV1 and LGR5 gene expression in endometrial cancer tissue and adjacent normal tissue were detected, and their median was referred to divide the patients into high TRPV1 group and low TRPV1 group as well as high LGR5 group and low LGR5 group, 20 cases in each group. The differences in proliferation and invasion gene expression in endometrial cancer tissues with different TRPV1 and LGR5 expression were compared. Results:TRPV1 and LGR5 gene expression in endometrial cancer tissues were significantly higher than those in adjacent tissues. Proliferation genes HMGB1, SRPX2 and Wip-1 mRNA expression in lesion tissues of high TRPV1 group and high LGR5 group were higher than those of low TRPV1 group and low LGR5 group respectively whereas ITLN-1 mRNA expression were lower than those of low TRPV1 group and low LGR5 group respectively;invasion genes MTA1, hnRNP H and Snail mRNA expression in lesion tissues of high TRPV1 group and high LGR5 group were higher than those of low TRPV1 group and low LGR5 group respectively whereas Dickkopf and DKK1 mRNA expression were lower than those of low TRPV1 group and low LGR5 group respectively.Conclusions:TRPV1 and LGR5 expression abnormally increase in endometrial cancer, which are directly correlated with the expression of downstream proliferation and invasion genes, and can affect the progress of the disease together.
