摘要
Objective: To investigate the correlation of abnormal Toll-like receptor 4 (TLR4) /Myeloid differentiation factor 88 (MyD88) expression with ectopic cell proliferation and invasion in endometriosis lesions. Methods: Patients undergoing surgical treatment for ovarian endometriosis in Shenmu Hospital between April 2013 and July 2017 were selected as endometriosis (EMs) group, and patients undergoing surgical treatment due to uterine fibroids in Shenmu Hospital during the same period were selected as control group. The ectopic endometrium tissue was collected from EMs group and the eutopic normal endometrium tissue was collected from control group to determine the mRNA expression of TLR4/MyD88 as well as cell proliferation and invasion regulation genes. Results: TLR4, MyD88, cFLIP, Nanog, Oct4, eIF4E, Twist1, Twist2 and MMP1 mRNA expression in ectopic endometrium tissue of EMs group were significantly higher than those in eutopic normal endometrium tissue of control group whereas LC3, Smac, Bak, E-cadherin, TIMP1 and TIMP2 mRNA expression were significantly lower than those in eutopic normal endometrium tissue of control group;TLR4 and MyD88 mRNA expression in ectopic endometrium tissue of EMs group were negatively correlated with LC3, Smac, Bak, E-cadherin, TIMP1 and TIMP2 mRNA expression, and positively correlated with cFLIP, Nanog, Oct4, eIF4E, Twist1, Twist2 and MMP1 mRNA expression. Conclusion: The abnormal high expression of TLR4/MyD88 in the endometriosis lesion can promote the proliferation and invasion of ectopic cells.
