摘要
Objective: To study the effects of ozone combined with sodium hyaluronate intracavitary injection on inflammatory mediators and oxidative stress in knee osteoarthritis. Methods:Patients who were diagnosed with moderate to severe knee osteoarthritis in Tangshan Hongci Hospital between July 2014 and March 2017 were selected and randomly divided into two groups, experimental group accepted ozone combined with sodium hyaluronate intracavitary injection, and control group accepted intracavitary injection of sodium hyaluronate. The joint fluid samples were collected before and after treatment respectively to determine the contents of inflammatory and oxidative stress signal molecules, inflammatory mediators and oxidative stress molecules. Results: After treatment, p38MAPK, MEK-3/6, NF-kB, TAK1, CXCL12, YKL40, IL1β, TNF , PGE2, MDA, GRP78 and CHOP levels in joint fluid of both groups of patients were significantly lower than those before treatment whereas GPx levels were higher than those before treatment, and p38MAPK, MEK-3/6, NF-kB, TAK1, CXCL12, YKL40, IL1β, TNF , PGE2, MDA, GRP78 and CHOP levels in joint fluid of experimental group were significantly lower than those of control group whereas GPx level was higher than that of control group. Conclusion: Ozone combined with sodium hyaluronate intracavitary injection can inhibit the local inflammatory response and oxidative stress response in patients with knee osteoarthritis.
