摘要
Objective: To study the correlation of FMNL2 and HERC4 expression with the infiltrative growth of cancer cells in cervical cancer tissue. Methods: Patients with cervical cancer who underwent surgical resection in our hospital between July 2014 and September 2016 were selected as the research subjects, the cervical cancer tissue and adjacent tissue were collected from the enrolled patients after operation to extract RNA, and PCR reaction kit was used to determine the mRNA expression of FMNL2, HERC4, epithelial mesenchymal transition genes and proliferation genes. Results: FMNL2, HERC4, Exosomes, Cripto-1, ZEB1, Snail, Vimentin, Piwil2, STOML-2, BCL-2, Smo and XIAP mRNA expression in cervical cancer tissue were significantly higher than those in adjacent tissue;Exosomes, Cripto-1, ZEB1, Snail and Vimentin mRNA expression in cervical cancer tissue with high FMNL2 expression were significantly higher than those in cervical cancer tissue with low FMNL2 expression;Piwil2, STOML-2, BCL-2, Smo and XIAP mRNA expression in cervical cancer tissue with high HERC4 expression were significantly higher than those in cervical cancer tissue with low HERC4 expression. Conclusion: The high expression of FMNL2 and HERC4 in cervical cancer tissue can promote the epithelial mesenchymal transition and proliferation of cancer cells respectively so as to participate in the infiltrative growth of cancer cells.
