摘要
Objective: To explore the effect of Saccharomyces boulardii (S. boulardii) in combined with Ruianji oral liquid on the cellular immune function in children with rotavirus enteritis (RVE). Methods: A total of 96 children with RVE who were admitted in our hospital from August, 2016 to July, 2017 were included in the study and randomized into the observation group and the control group with 48 cases in each group. The patients in the two groups were given water-electrolyte and acid-base balance maintaining, antivirus, and fluid infusion. The patients in the control group were given Ruianji oral liquid, 5 mL/time from 5 months to 12 months, 2 times/d;5 mL/time greater than 12 months, 3 times/d. On the above basis, the patients in the observation group were given S. boulardii, 0.125 g/time when less than 12 months, 1 time/d;0.25 g/time when greater than 12 months, 2 times/d, taking with warm water. After 1-week treatment, the efficacy was evaluate. The fasting peripheral venous blood before and after treatment in the two groups was collected. ELISA was used to detect the serum TNF-α, IL-6, and IL-8. FCM was used to detect CD3+, CD4+, and CD8+. CD4+/CD8+ was calculated. SRID was sued to detect IgA and IgG. Results: TNF-α, IL-6, and IL-8 after treatment in the observation group were significantly lower than those in the control group. CD3+, CD4+, and CD4+/CD8+after treatment in the observation group were significantly higher than those in the control group, while CD8+ was significantly lower than that in the control group. IgA and IgG after treatment in the observation group were significantly higher than those in the control group. Conclusions: S. boulardii in combined with Ruianji oral liquid can inhibit the expressions of inflammatory cytokines in children with RVE, strengthen the cellular immune function, and effectively improve the clinical symptoms.
