摘要
Objective: To study the effects of operation combined with chemotherapy on MMP-2, TIMP-1, VEGF, NSE, LDH and immunologic function in children with neuroblastoma (NB). Methods: A total of 90 children with NB in our hospital from January 2014 to January 2017 were enrolled in this study. The subjects were divided into the control group (n=45) and the treatment group (n=45) randomly. The control group was treated with operation for 7 periods;the treatment group was treated with operation combined with chemotherapy for 7 periods. The serum MMP-2, TIMP-1, VEGF, NSE, LDH, IgG, IgA, IgM, IgE and peripheral blood TTL, THL, TSL, NK, CD4+/CD8+ of the two groups before and after treatment were compared. Results: There were no significantly differences of the serum MMP-2, TIMP-1, VEGF, NSE, LDH of the two groups before treatment. The serum MMP-2, TIMP-1, VEGF, NSE, LDH of the two groups after treatment were significantly lower than before treatment, and that of the treatment group after treatment were significantly lower than the control group. There were no significantly differences of the serum IgG, IgA, IgM, IgE of the two groups before treatment. The serum IgG, IgA, IgM, IgE of the two groups after treatment were significantly lower than before treatment, and that of the treatment group after treatment were significantly lower than the control group. There were no significantly differences of the peripheral blood TTL, THL, TSL, NK, CD4+/CD8+ of the two groups before treatment. The peripheral blood TTL, CD4+/CD8+ of the two groups after treatment were significantly lower than before treatment, the peripheral blood THL, TSL, NK of the two groups after treatment were significantly higher than before treatment, and that of the treatment group after treatment were significantly better than the control group. Conclusion: Operation combined with chemotherapy can inhabit the tumor infiltration and metastasis of the children with NB, can improve the cellular immunity function, and it was worthy clinical application.
