摘要
Objective: To study the effect of perioperative arterial infusion chemotherapy on the proliferation and invasion of cancer cells in resectable pancreatic cancer lesion. Methods:Patients who received radical operation for pancreatic cancer in Yidu First People's Hospital between February 2015 and April 2017 were selected as the research subjects and randomly divided into the infusion chemotherapy group who received preoperative arterial infusion chemotherapy and normal control group who received routine preoperative intervention. After surgical resection, the pancreatic cancer lesion was collected to determine the mRNA expression of pro-proliferation genes, anti-proliferation genes and invasion genes. Results:Mdig, XIAP, Survivin, USP9X, CyclinD1, MSX2, TPM3, Twist, Snail and Del-1 mRNA expression in pancreatic cancer lesions of infusion chemotherapy group were significantly lower than those of normal control group while ARHI, ING4, PTEN and Kail mRNA expression were significantly higher than those of normal control group. Conclusion:Preoperative arterial infusion chemotherapy can reduce the proliferation and invasion of cancer cells in resectable pancreatic cancer lesions.
