摘要
Objective: To study the effect of calcium alginate dressing on the cytokine contents, collagen synthesis - degradation balance and apoptosis gene expression in the wound after perianal abscess surgery. Methods: Patients with perianal abscess who received surgical resection in the Eighth Hospital of Wuhan between May 2014 and February 2017 were selected and randomly divided into the group A who received calcium alginate dressing combined with kangfuxin solution and recombinant human epidermal growth factor for dressing change and the group B who received kangfuxin solution and recombinant human epidermal growth factor for dressing change. 3 d, 6 d and 9 d after dressing change, appropriate amount of wound tissue was collected to determine the expression of cytokines, collagen metabolites and apoptosis genes. Results: 3 d, 6 d and 9 d after dressing change, TGF-β1, Smad3, EGF and bFGF protein expression as well as Col-I, Col-II, Col-III, TIMP1 and TIMP2 protein expression in wounds of both groups of patients were increasing while Fas, FasL, Bax and Caspase-3 protein expression were decreasing, and TGF-β1, Smad3, EGF and bFGF protein expression as well as Col-I, Col-II, Col-III, TIMP1 and TIMP2 protein expression in wounds of group A were significantly higher than those of group B while Fas, FasL, Bax and Caspase-3 protein expression were significantly lower than those of group B. Conclusion: Calcium alginate dressing for wound dressing after perianal abscess surgery an increase the pro-proliferation cytokine expression, adjust the collagen synthesis - degradation balance and inhibit apoptosis, and it is conducive to wound healing.
