摘要
Objective:To study the correlation of MMP-2 gene polymorphism with disease relapse as well as inflammatory mediators and oxidative stress molecules in patients with ischemic stroke. Methods: Patients with primary and recurrent ischemic stroke who were treated in Shaanxi Provincial People's Hospital between January 2015 and December 2016 were selected as the primary group and recurrent group respectively;healthy volunteers who received physical examination during the same period were selected as control group. Serum MMP-2 gene polymorphism and inflammatory mediator levels as well as peripheral blood oxidative stress molecule expression were determined.Results: Serum MMP2 gene 735 loci CC genotype constituent ratio of recurrent group was significantly higher than that of control group and primary group while CT genotype and TT genotype constituent ratio were significantly lower than those of control group and primary group;serum HMBG1, FKN, TNF-α, IL-1β and IL-17 levels as well as peripheral blood Keap1 mRNA expression in stoke patients with MMP2 gene CC genotype were significantly higher than those in stoke patients with MMP2 gene CT genotype and MMP2 gene TT genotype while peripheral blood Nrf2, ARE, NQO1 and HO1 mRNA expression were significantly lower than those in stoke patients with MMP2 gene CT genotype and MMP2 gene TT genotype.Conclusions:MMP-2 gene CC genotype in patients with ischemic stroke can aggravate inflammatory response and oxidative stress response, and is closely related to disease relapse.
