摘要
Objective:To study the changes in PD-1/PD-L1 pathway function in non-small cell lung cancer tissue before and after125I seed implantation.Methods: Patients with advanced non-small cell lung cancer who were treated in Dongguan Kanghua Hospital between May 2014 and April 2017 were selected and randomly divided into125I group and control group who received125I seed implantation combined bronchial artery infusion chemotherapy embolism and bronchial artery infusion chemotherapy embolism alone respectively. The expression of PD-1, PD-L1, transcription factors and tumor suppressor genes in lung cancer lesions were determined before and after treatment.Results: PD-1, PD-L1 and Foxp3 mRNA expression and protein expression in lesions of both groups after treatment were significantly lower than those before treatment while T-bet, PTEN, TCF21 and LATS1 mRNA expression and protein expression were significantly higher than those before treatment, and PD-1, PD-L1 and Foxp3 mRNA expression and protein expression in lesions of125I group after treatment were significantly lower than those of control group while T-bet, PTEN, TCF21 and LATS1 mRNA expression and protein expression were significantly higher than those of control group. Conclusion:125I seed implantation treatment of advanced non-small cell lung cancer can inhibit the immune escape of cancer cells mediated by PD-1/PD-L1 pathway, and promote the apoptosis of cancer cells.
