摘要
Objective:To study the effect of acupuncture intervention on the intestinal mucosal inflammatory response and immune response balance in animals with ulcerative colitis (UC).Methods:Adult, male SPF SD rats were selected and randomly divided into the control group, UC group and acupuncture group, and then the acupuncture intervention was established after the UC animal model was established. 14 d after intervention, the expression of inflammatory mediators and Th1/Th2/Th17/Treg cytokines in intestinal mucosa, and the levels of inflammatory mediators and Th1/Th2/Th17/Treg cytokines in serum were detected. Results:NF-kB, HMGB-1, TNF-α, IL-1β, IFN-γ and IL-17 mRNA expression in intestinal mucosa as well as HMGB-1, TNF-α, IL-1β, IFN-γ and IL-17 levels in serum of UC group were significantly higher than those of control group while IL-4, IL-5 and TGF-β1 mRNA expression in intestinal mucosa as well as IL-4, IL-5 and TGF-β1 levels in serum were significantly lower than those of control group;NF-kB, HMGB-1, TNF-α, IL-1β, IFN-γ and IL-17 mRNA expression in intestinal mucosa as well as HMGB-1, TNF-α, IL-1β, IFN-γ and IL-17 levels in serum of acupuncture group were significantly lower than those of UC group while IL-4, IL-5 and TGF-β1 mRNA expression in intestinal mucosa as well as IL-4, IL-5 and TGF-β1 levels in serum were significantly higher than those of UC group. Conclusions: Acupuncture intervention can regulate the intestinal mucosal inflammatory response and immune response of animals with ulcerative colitis.
