摘要
Objective:To study the effect of Danhong injection on neuroethology changes, cell injury and apoptosis in rats with cerebral infarction.Methods: SD rats were selected as experimental animals and divided into control group, cerebral infarction group and Danhong group, control group received sham operation, cerebral infarction group were made into cerebral infarction animal models and Danhong group were made into cerebral infarction animal models and then received Danhong injection for intervention. After the intervention, water maze experiment was used to assess the neuroethology changes of rats, and the serum and brain tissue were collected to determine nerve injury molecules and apoptosis molecules.Results: 2 weeks, 4 weeks and 6 weeks after intervention, the escape latency and the course to find platform of cerebral infarction group were higher than those of control group and the number of platform crossing were lower than those of control group;the escape latency and the course to find platform of Danhong group were lower than those of cerebral infarction group, and the number of platform crossing were higher than those of cerebral infarction group;6 weeks after intervention, CK-BB, LDH, NSE and S100β levels in serum as well as ROS, MDA, JNK1, JNK2, c-Jun, ATF-2 and Bax levels in brain tissue of cerebral infarction group were significantly higher than those of control group while GSH-PX, T-SOD and CAT levels in brain tissue were significantly lower than those of control group;CK-BB, LDH, NSE and S100β levels in serum as well as ROS, MDA, JNK1, JNK2, c-Jun, ATF-2 and Bax levels in brain tissue of Danhong group were significantly lower than those of cerebral infarction group while GSH-PX, T-SOD and CAT levels in brain tissue were significantly higher than those of cerebral infarction group. Conclusion:Danhong injection can reduce the neurocyte damage and inhibit the neurocyte apoptosis to improve the neurological function of rats with cerebral infarction.
