摘要
Objective:To evaluate the changes in serum index levels after monosialoganglioside injection combined with conventional treatment of neonatal hypoxic ischemic encephalopathy. Methods:A total of 70 children with neonatal hypoxic ischemic encephalopathy treated in our hospital between February 2013 and February 2016 were selected and randomly divided into observation group and control group, control group received clinical routine treatment and observation group accepted monosialoganglioside injection combined with conventional treatment. After 1 week of treatment, serum levels of apoptosis factors, nerve function indexes, oxidation/anti-oxidation indexes and disease severity indexes of two groups of patients were detected.Results:Serum PDCD5, sFas, sFasL, NSE, S100-β, MDA, NO, NOS, H-FABP, NPY, caspase-1 and ET-1 levels of observation group were lower than those of control group while BDNF, NGF, SOD, GSH-PX, IGF-1 and GH levels were higher than those of control group.Conclusion: Monosialoganglioside injection can enhance the overall treatment effect and promote the realization of homeostasis in children with HIE.
