摘要
Objective:To study the effect of perioperative fetal intrauterine hypoxia on maternal oxidative stress injury after cesarean section. Methods:37 puerperae receiving cesarean section for fetal intrauterine hypoxia between May 2014 and December 2016 were selected as hypoxia group and 40 puerperae receiving cesarean section during the same period and without complications during pregnancy or fetal intrauterine hypoxia were selected as control group. Umbilical arterial blood was collected after delivery of placenta for blood gas analysis, and the placenta tissue and serum samples were collected to test the content of oxidative stress products and antioxidants. Results:Umbilical arterial blood gas analysis parameters pH value as well as PO2, HCO3-and BE content of hypoxia group were significantly lower than those of control group (P<0.05);NADPH, reactive oxide species (ROS) and reactive nitrogen species (RNS) content in placenta tissue of hypoxia group were significantly higher than those of control group (P<0.05) while glutathione S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), Trx, vitamin C (VitC), VitE and coenzyme Q10 (CoQ10) content were significantly lower than those of control group (P<0.05);serum malondialdehyde (MDA) and 8-iso-prostaglandin F2α(8-iso-PGF2α) content of hypoxia group were significantly higher than those of control group (P<0.05). Conclusions:Perioperative fetal intrauterine hypoxia can lead to maternal oxidative stress injury after cesarean section and increase the generation of free radicals and the consumption of antioxidants.
