摘要
Objective:To explore the effect of hydromorphone hydrochloride postoperative analgesia on the stress reaction and hemorheology in elderly patients after total hip replacement (THR). Methods:A total of 70 patients who were admitted in our hospital from June, 2015 to June, 2016 for THR were included in the study and randomized into the observation group and the control group with 35 cases in each group. After operation, the patients in the two groups were immediately given patient-controlled analgesia. The patients in the observation group were given hydromorphone hydrochloride, while the patients in the control group were given sufentanil. The peripheral venous blood before operation, 12 and 24 h after operation in the two groups was collected. RIA was used to detect BG and Cor. ELISA was used to detect NE. The peripheral venous blood before operation, 24 and 72 h after operation was collected. The full automatic hematology analyzer was used to detect the plasma PV, BV, and RWBV. Results:Cor and NE levels in the observation group, and BG, Cor, and NE levels in the control group 12 and 24 h after operation were significantly elevated when compared with before operation (P<0.05), but the above indicators at each timing point in the control group were significantly higher than those in the observation group (P<0.05). PV, BV (low-shear, middle-shear, and high-shear), and RWBV (low-shear, middle-shear, and high-shear) levels 24 and 72 h after operation in the two groups were significantly elevated when compared with before operation (P<0.05), but the above indicators at each timing point in the control group were significantly higher than those in the observation group (P<0.05). Conclusions:Application of hydromorphone hydrochloride in the postoperative analgesia in elderly patients with THR has a preferable analgesia effect, can effectively alleviate the postoperative stress reaction, stabilize the hemorheology, and contribute to the rehabilitation.
