三阴性乳腺癌中KIF5A的表达和临床意义

Expression and clinical significance of KIF5A in triple negative breast cancer

目的 探讨在三阴性乳腺癌组织中KIF5A的表达及其临床意义.方法 回顾性分析82例接受乳腺癌切除手术治疗的三阴性乳腺癌患者的临床病理资料.采用免疫组化的方法检测癌组织和对应的癌旁组织中KIF5A的表达,分析其与临床病理特征的关系.结果 KIF5A在三阴性乳腺癌组织中的阳性高表达率为63.4%,而在癌旁组织中为低或无表达.KIF5A的异常高表达与乳腺癌高分期和淋巴结转移相关(均P<0.05),而与患者的年龄、肿瘤分级、大小和脉管瘤栓无关(均P>0.05).生存分析提示,在三阴性乳腺癌中KIF5A高表达的患者生存时间明显短于低表达的患者(P<0.05).结论 三阴性乳腺癌组织中存在KIF5A的异常高表达,并与乳腺癌的高分期和淋巴结有转移有关,且KIF5A的高表达提示三阴性乳腺癌患者可能产生不良预后.

Objective To investigate the expression and clinical significance of KIF5A in triple negative breast cancer tissues.Methods The clinical and pathological data of 82 patients with triple negative breast cancer who underwent breast cancer resection were retrospectively analyzed.The expression of KIF5A in cancer tissues and corresponding adjacent tissues was detected by immunohistochemistry method,and its relationship with clinicopathological features was analyzed.Results The positive high expression rate of KIF5A in triple negative breast cancer tissues was 63.4%,but low or no expression in adjacent tissues.The abnormal expression of KIFSA was correlated with the TNM stage and Lymph node metastasis(all P<0.05),but not associated with age,tumor grade,size and vascular tumor thrombus(all P>0.05).Survival analysis indicated that patients with high KIF5A expression in triple negative breast cancer were significantly shorter than those with low KIF5A expression(P<0.05).Conclusions The abnormally high expression of KIF5A in triple negative breast cancer tissues is associated with high TNM and lymph node metastasis in breast cancer,and high expression of KIF5A suggests that patients with triple negative breast cancer may have poor prognosis.