摘要
Introduction Cutaneous squamous cell carcinoma (CSCC),a keratinocyte-derived skin neoplasm with malignant potential,1 represents 20%-50% of skin cancers and currently has an increasing incidence in the United States.2 Ultraviolet (UV)solar radiation is the primary risk factor for the development of CSCC,and the cumulative exposure received over a lifetime plays a major role in this development.3 Mutations in the p53 gene are the most common genetic abnormalities,causing nonfunctional p53 protein production and cells with damaged DNA replicate in CSCC.
基金
supported by Grants from the Chinese Academy Medical Sciences Initiative for Innovative Medicine (No. 2016I2M-3-021)
National Natural Science Foundation of China (No. 31470274)
Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs (No. 2012ZD006)
Jiangsu provincial SixTalent Peaks (No. 2013-WSW-060)