摘要
Introduction Tissue-resident memory T (TRM) cells are a subset of recently identified noncirculating memory T cells characterized by long-term persistence in nonlymphoid peripheral tissues such as the skin,gut,lung,kidney,and reproductive tract[1].The skin is the largest organ in the human body,and estimated 2 × 1010 T cells are present in the entire skin surface.Most of these are CD45RO + memory T cells that express the skin-homing addressins cutaneous leukocyte antigen (CLA) and chemokine receptor (CCR) 4[2].
