神经母细胞瘤转移相关机制研究进展

Research progress in the mechanisms related to metastasis in neuroblastoma

神经母细胞瘤(NB)好发于5岁以下婴幼儿,遗传学异常和临床表型存在高度异质性。即使通过强烈联合化疗、造血干细胞移植、诱导分化和免疫治疗等综合性治疗策略,相当部分转移性NB的预后仍很不理想。深入研究NB转移相关机制,对于靶向干预相关环节,提高NB疗效和预后具有重要临床现实意义。本文介绍转移性NB的流行病学现状和预后,总结NB进展和转移相关研究领域的近期研究进展。

Neuroblastoma(NB)is primarily prevalent in infants and young children under 5 years,and is highly hetergeneous both in terms of genetic aberrations and clinical phenotypes.Even with multi-modality treatment including intensive combination chemotherapy,hematopoietic stem cell transplantation,differentiation induction and immunotherapy,the prognosis of metastatic NB in a great majority of patients is still far from optimal.Therefore,a better understanding of the mechanisms underlying NB metastasis is of great clinical importance as regard to fomulation of novel interventional strategies,and further improvement of therapeutic efficacy and clinical outcomes.In the present review,recent research advances related to NB progression and metastasis are summarized.