普通话版耳鸣问卷评分变化与耳鸣治疗效果的一致性

The consistency between changes in Mandarin Tinnitus Questionnaire scores and tinnitus treatment outcomes

目的验证普通话版耳鸣问卷(MTQ)评分变化与耳鸣治疗效果的一致性。方法前瞻性纳入2020年9月至2021年9月在四川大学华西医院耳鼻咽喉头颈外科就诊的耳鸣患者,通过医师评估、患者自评、MTQ和视觉模拟量表(VAS)对患者耳鸣严重程度进行评估。治疗3~6个月后进行随访,评估患者治疗后耳鸣严重程度,收集患者接受的干预治疗手段[药物治疗(药物组)/非药物治疗(非药物组)]、治疗后的自我临床印象(耳鸣治愈/改善/无变化/加重),评估MTQ评分变化与耳鸣治疗效果的一致性。结果共纳入54例耳鸣患者,其中男16例,女38例,年龄(43.5±12.7)岁。药物组38例,非药物组16例;药物治疗组原发性耳鸣比例高于非药物治疗组[97.4%(37/38)比75.0%(12/16),P=0.023],其余基线临床资料差异均无统计学意义(均P>0.05)。初诊、复诊时MTQ评分与医师评估(r=0.679、0.774)、患者自评(r=0.483、0.779)及VAS(r=0.606、0.756)得分均呈正相关(均P<0.001)。治疗后MTQ评分变化值(ΔMTQ)与VAS得分变化值(ΔVAS)呈正相关(r=0.694,P<0.001);Bland-Altman分析结果显示,ΔMTQ与ΔVAS的平均差值为3.704×10-7,95%的一致性界限为-1.534~1.534;药物组与非药物组ΔVAS、ΔMTQ差异均无统计学意义(均P>0.05)。结论耳鸣患者MTQ评分与医师评估、患者自评及VAS得分相关性良好,MTQ评分变化与耳鸣治疗效果一致。

Objective To verify the consistency between changes in Mandarin Tinnitus Questionnaire(MTQ)scores and tinnitus treatment outcomes.Methods Tinnitus patients attending the Department of Otorhinolaryngology-Head&Neck Surgery,West China Hospital of Sichuan University from September 2020 to September 2021were prospectively enrolled.The tinnitus severity was evaluated by the doctor′s assessment,the patient′s self-assessment,the MTQ,and the Visual Analogue Scale(VAS).Follow-up assessments were conducted 3 to 6 months later to evaluate the severity of tinnitus post-treatment,and information on the interventions received(pharmacologic/non-pharmacologic)and patients′self-reported clinical impressions of their treatment outcomes(tinnitus cured/improved/no change/exacerbated)was collected.Results A total of 54 tinnitus patients aged(43.5±12.7)years were included,consisting of 16 males and 38 females.There were 38 cases in the medication group and 16 cases in the non-medication group.No statistically significant differences in baseline clinical data were observed(all P>0.05).The proportion of primary tinnitus in the medication group was higher than that in the non-medication group[97.4%(37/38)vs 75.0%(12/16),P=0.023].The correlation coefficients of MTQ scores at the initial and follow-up visits with doctor′s assessment,patient′s self-assessment,and VAS scores were 0.679,0.483,0.606,0.774,0.779,and 0.756,respectively(all P<0.001).TheΔMTQ correlation coefficient withΔVAS was 0.694(P<0.001),with a mean difference of 3.704×10-7 and 95%limits of agreement ranging from-1.534 to 1.534 in Bland-Altman analysis.There were no statistically significant differences ofΔVAS andΔMTQ between two groups(both P>0.05).Conclusions MTQ correlates well with the doctor′s assessment,the patient′s self-assessment,and VAS.Changes in MTQ scores associate well with changes in VAS scores.Additionally,changes in MTQ scores are consistent with the effect of tinnitus treatment.