摘要
To the Editor:Cutaneous squamous cell carcinoma(CSCC)originates from the keratinocytes of the epidermal layer and(or)its associated appendages,manifesting as a rapidly proliferating,highly destructive malignancy,with almost 20,000 cases occurring in China in 2022.[1]The pathogenesis of CSCC is complex,but recent studies have made significant progress.Our previous research identified eight proteins,including actinin alpha 1(ACTN1),tenascin C(TNC),fascin actin-bundling protein 1(FSCN1),serpin family B member 1(SERPINB1),ras-related protein 31(RAB31),collagen type III alpha 1 chain(COL3A1),collagen type I alpha 1 chain(COL1A1),and cluster of differentiation 36(CD36),which are markedly linked to CSCC invasion and metastasis.[2]Besides,our subsequent assays also revealed the elevated serum level of ACTN1 in CSCC patients,which correlated with tumor cell differentiation,invasion depth,and primary tumor diameter.[3]This underscores the potentially pivotal role of ACTN1 in CSCC pathogenesis.This study aimed to further investigate the role of ACTN1 in the pathogenesis of CSCC.
基金
supported by 2021 Natural Science Research Project of Universities from Anhui Province(No.KJ2021ZD0097)
2023 Key Research Projects from Universities in Anhui Provinces(No.2023AH051781)
National Natural Science Foundation of Anhui(No.2308085QH269)
the Key Research Project of Wannan Medical College in 2022(Nos.WK2022ZF09 and WK2022F19).
