Amide proton transfer:A new magnetic resonance imaging technology toward individualized assessment

To the Editor:The amide proton transfer(APT)magnetic resonance imaging(MRI)is an emerging molecular imaging method for detecting mobile proteins/peptides and the potential of hydrogen(pH)with enhanced detection sensitivity compared to direct measurement without external magnetic resonance contrast agents[Figure 1].Such changes may be potential markers for tumor aggressiveness,treatment efficacy,and overall prognosis.Consequently,the utilization of APT can assist medical professionals in devising treatment regimens tailored to the individual needs of cancer patients,resulting in improved therapeutic outcomes.