砷暴露诱导代谢改变的研究进展

Recent advances in the study of metabolic changes induced by arsenic exposure

砷是一种广泛存在于自然环境中的类金属元素,是世界卫生组织(WHO)确定的一级致癌物之一,但具体的致癌机制目前尚未明确。近些年,通过对砷的毒理学研究,发现砷暴露可影响机体细胞代谢,这种影响可能与砷的致癌机制存在重要关联。因此,作者综述了有关砷暴露影响糖、脂质、氨基酸代谢的研究进展,以期为砷致癌作用机制的研究提供理论依据。

Arsenic is a widely occurring metalloid element in the natural environment and is one of the primary carcinogens identified by the World Health Organization(WHO),but the specific carcinogenic mechanism is currently unclear.In recent years,through toxicological studies on arsenic,it has been found that exposure to arsenic can affect cellular metabolism in the body,which may be closely related to the carcinogenic mechanism of arsenic.Therefore,the authors review the research progress on arsenic exposure-induced effects on glucose metabolism,lipid metabolism,and amino acid metabolism,with a view to providing a theoretical basis for the study of the mechanism of arsenic carcinogenesis.