圆锥角膜胶原交联在体生物力学效应研究进展

Advances in In-Vivo Biomechanical Effects of Corneal Cross-Linking for Keratoconus

角膜胶原交联是进展性圆锥角膜的首选手术治疗方案,其诱导角膜胶原形成共价交联,改变了角膜组织结构及生物力学特性。生物力学测量方法在评估角膜交联手术疗效方面展现出巨大的潜力。现就目前临床上应用的在体角膜生物力学评估方法及圆锥角膜胶原交联对在体角膜生物力学的影响进行综述。

Corneal cross-linking(CXL)is the preferred surgical therapy for progressive keratoconus.It can promote the formation of the covalent cross-linking,therefore modifies the corneal structure and biomechanical properties.Biomechanical measurements have great potential for assessing the efficacy of the CXL.In this review,we summarize the currently available in-vivo corneal biomechanical measurements in clinical practice and the effect of CXL on corneal biomechanical properties in vivo.