基于电子病历数据分析不同性别肺癌手术患者流行病学特征的差异

Differential epidemiological characteristics of lung cancer surgical patients with different gender based on analysis of electronic medical record data

目的探讨不同性别肺癌手术患者流行病学特征(人口社会学、临床信息及病理、影像特征)的差异。方法回顾性收集单中心医院电子病历系统2016—2019年胸外科具有完整人口社会学、临床信息及病理、影像特征的肺癌手术患者2058例,其中男性1244例,女性814例,分析不同性别肺癌手术患者流行病学特征的差异。结果女性患者吸烟率和鳞癌比例低于男性(3.2%比78.8%、3.3%比36.6%),中青年、腺癌、腺体前驱病变、病理分期0期、Ⅰ期、亚肺叶切除比例女性高于男性患者(59.2%比48.2%、87.5%比55.1%、5.6%比1.3%、5.6%比1.3%、74.9%比56.9%、6.0%比3.8%),淋巴结处理方式并无明显差异(P>0.05)。结论肺癌手术患者人口社会学、手术方式及病理、影像特征存在性别差异,女性患者比男性更年轻、病灶更小,非吸烟者、腺体前驱病变、早期患者比例更高,从而手术方式更加倾向于微创。

Objective To investigate the gender-specific epidemiological(sociodemographic,clinical,pathological and radiological)characteristics of surgically treated lung cancer patients.Methods This study retrospectively analyzed the epidemiological data of the 2058 lung cancer patients(male 1244,female 814)surgically treated in the department of chest surgery in a grade-A tertiary hospital from 2016 to 2019 that have complete sociodemographic,clinical,pathological and radiological data.Gender-specific differences in these data were examined.Results Compared with the male patients,the female patients had a lower rate of smoking(3.2%vs.78.8%)and squamous cell carcinoma(3.3%vs.36.6%),but they were higher in the propration of the youth and middle-aged,adenocarcinoma,glandular prodromal lesions,Tumor-Node-Metastasis(TNM)Stage 0 and StageⅠ,and received sublobar resection than male patients(59.2%vs 48.2%,87.5%vs 55.1%,5.6%vs 1.3%,5.6%vs 1.3%,74.9%vs 56.9%,6.0%vs 3.8%,respectively).Conclusion Gender differences were observed in the sociodemographic characteristics,surgical approaches,and pathological or radiological features of surgically treated lung cancer patients.Female patients were typically younger,had smaller lesions,and more likely to be non-smokers and to have adenocarcinoma precursor lesions and early-stage disease compared to male patients,and therefore,were more likely to had received minimally invasive surgeries.