阴茎胚胎发育与尿道下裂发生的研究进展

Research advances of penile embryonic development and hypospadias

阴茎是男性外生殖器的一部分,其结构和功能的异常会产生严重生理影响和社会心理影响。在胚胎发育的早期,原始胚基是双向分化的,直到18周左右才形成严格意义上的阴茎,其过程对理解尿道下裂等先天畸形的发生以及手术修复的探索有指导意义。本文旨在综述近年来阴茎组织胚胎学发育和尿道下裂发生的研究进展,包括正常情况下的早期胚胎发育、胚胎时期尿道及包皮的发育过程,以及发育异常情况下尿道下裂的发生过程。

Penis is an integral part of male external genitalia.Its abnormal structures and functions may cause serious physiological and psychosocial effects.Embryonic development is essential for penile formation and aids in understanding the occurrence of hypospadias and other congenital malformations and exploring surgical repairs.This review focused upon the latest advances of penile developments,hypospadias,early embryogenesis under normal conditions,embryonic development of urethra and malformations of prepuce and hypospadias under abnormal conditions.