Experimental research on spinal metastasis with mouse models

To the Editor:The spine is a common site for tumor metastasis.Patients with spinal metastases have pain,pathological fractures and spinal deformities owing to the tumor invasion of spinal bones.At present,the mouse model is a very important tool for spinal metastases-related studies.[1]It is crucial to elucidate the pathophysiological mechanism underlying spinal metastases,improve the diagnosis and treatment guidelines,and develop new therapeutic methods.In this study,we have summarized various mouse spinal metastasis models and the applicable research contents.