摘要
Over the past few years,the human virome and its complex interactions with microbial communities and the immune system have gained recognition as a crucial factor in human health.Individuals with compromised immune function encounter distinctive challenges due to their heightened vulnerability to a diverse range of infectious diseases.This review aims to comprehensively explore and analyze the growing evidence regarding the role of the virome in immunocompromised disease status.By surveying the latest literature,we present a detailed overview of virome alterations observed in various immunodeficiency conditions.We then delve into the influence and mechanisms of these virome changes on the pathogenesis of specific diseases in immunocompromised individuals.Furthermore,this review explores the clinical relevance of virome studies in the context of immunodeficiency,highlighting the potential diagnostic and therapeutic gains from a better understanding of virome contributions to disease manifestations.
基金
supported by grants from the Start-up Foundation of Tsinghua University(No.400-53332101822)
the Tsinghua-Peking Center for Life Sciences(No.045-61000100122)
the National Key R&D Program of China(Nos.2021YFC2301900 and 2021YFC2301905)
the National Natural Science Foundation of China(Nos.32200036 and 81974303)
the Beijing Natural Science Foundation(Nos.L222068 and Z220018)
the High-Level Public Health Specialized Talents Project of Beijing Municipal Health Commission(No.2022-2-018)
the Beijing Key Laboratory for HIV/AIDS Research(No.BZ0089)
