莱菔硫烷在恶性肿瘤治疗中的作用进展

Progress in the role of sulforaphane in the treatment of malignant tumors

莱菔硫烷(SFN)是十字花科蔬菜中富含的一种异硫氰酸盐,是具有较强抗癌活性的植物活性物质之一。SFN能保护细胞免受环境致癌物的伤害,诱导多种癌细胞生长阻滞和凋亡。本文就SFN在肿瘤预防、治疗及在肿瘤干细胞中的作用等方面的研究进展进行综述,探讨在临床中应用SFN进行癌症预防的可行性,并为减少恶性肿瘤的发展和复发从而提高患者的生存率提供新策略。

Sulforaphane(SFN)is an isothiocyanate rich in cruciferous vegetables,and is one of the plant active substances with strong anticancer activity.SFN can protect cells from environmental carcinogens and induce growth arrest and apoptosis of various cancer cells.This article reviews the research progress of SFN in tumor prevention,treatment,and its role in tumor stem cells,explores the feasibility of SFN in clinical application for cancer prevention,and provides new strategies to reduce the development and recurrence of malignant tumors and improve patient survival.