对老年特应性皮炎的再认识

Reunderstanding of atopic dermatitis in the elderly

特应性皮炎(AD)是一种高度异质性的皮肤病,老年AD在很多方面均具有不同于其他年龄段的特点,容易误诊、漏诊,近年来逐渐得到认识和重视。老年AD的发病与衰老相关的屏障和免疫功能改变有关,皮肤炎症模式更偏向Th1型炎症,临床表现具有一定的“反向”特征。老年AD的诊断应做好排除性诊断,在治疗上除了依据阶梯治疗理念,还需根据老年人的皮肤特征、合并症等因素进行个体化选择。

Atopic dermatitis(AD)is a highly heterogeneous skin disease.Many characteristics of AD in the elderly are different from those in other age groups,and AD in the elderly is prone to misdiagnosis or missed diagnosis,which has gradually gained recognition and attention in recent years.The onset of elderly AD is related to changes of aging related barrier and immune function.Elderly AD is more common in Th1 type of skin inflammation,and has certain"reverse"characteristics in clinical manifestations.The diagnosis of elderly AD should be based on exclusion diagnosis.In addition to the stepwise treatment,personalized treatment should also be made based on factors,such as skin characteristics and comorbidities of the elderly.