脂肪来源干细胞及其衍生物应用于慢性难愈性创面的研究进展

Research advances on the application of adipose-derived stem cells and their derivatives in the treatment of chronic wounds

慢性创面发病机制复杂且病程长,其治疗一直是医学领域中最具挑战性的问题之一。近年来,脂肪来源干细胞(ADSCs)疗法在慢性创面治疗中的研究得到了长足发展,随着对细胞行为和信号通路的深入探究及衍生物提取技术的进步,干细胞的应用不断得到创新。该文从创面正常愈合和难愈合的机制出发,探讨ADSCs及其衍生物对慢性难愈性创面的影响,对相关研究进行综述。

The treatment of chronic wounds has been one of the most challenging problems in the medical field due to their complex pathogenesis and long course.In recent years,the research of adipose-derived stem cells(ADSCs)therapy in the treatment of chronic wounds has been greatly developed.The application of stem cells has been innovated with the further investigation of cell behavior and signaling pathways,and the advancement of derivative extraction technology.In this article,the effects of ADSCs and their derivatives on chronic wounds are discussed in terms of the mechanisms of normal and chronic wound healing,and the related studies are reviewed.