摘要
Copper plays an important role in many metabolic activities in the human body.Copper level in the human body is in a state of dynamic equilibrium.Recent research on copper metabolism has revealed that copper dyshomeostasis can cause cell damage and induce or aggravate some diseases by affecting oxidative stress,proteasome,cuprotosis,and angiogenesis.The liver plays a central role in copper metabolism in the human body.Research conducted in recent years has unraveled the relationship between copper homeostasis and liver diseases.In this paper,we review the available evidence of the mechanism by which copper dyshomeostasis promotes cell damage and the development of liver diseases,and identify the future research priorities.
基金
sponsored by the National Natural Science Foundation of China(Nos.81972265,82170602)
the National Natural Science Foundation of Jilin Province(No.20200201324JC)
the Project for Middle-aged and Young Excellent Technological Innovation Talents of Jilin Province(No.20220508079RC)
the Project for Health Talents of Jilin Province(No.JLSWSRCZX 2021-079).
