Metabolite alpha-ketoglutarate:a novel target of gasdermin C-dependent pyroptosis

To the Editor:Tumors are one of the main causes of death worldwide.Pyroptosis is a newly discovered form of cell death,causing cell swelling and rapid lysis,which releases pro-inflammatory mediators and enhances the inflammatory response.[1]Inflammation increases the immune response to tumors and inhibits their progression.The ultimate goal of cancer therapeutics is to maximize the destruction of tumor cells while minimizing the damage to normal tissues.[2]Targeting pyroptosis of tumor cells could overcome the apoptotic resistance and trigger antitumor immunity,thus being a good treatment for tumors.