Targeting senescent dermal fibroblasts responsible for hyperactive melanocytes in melasma

Melasma(chloasma)is a highly prevalent and cosmetically disfiguring pigmented skin disease that mainly manifests as bilateral irregular brown macules on sun-exposed areas of the face.[1]Although melasma causes no physical discomfort,it poses a significant psychological burden on patients due to distressing cosmetic concerns.The sustained epidermal hypermelanization is a prominent pathological feature of melasma,which is usually considered to result from melanin overproduction by hyperactive melanocytes.[2]However,existing therapeutic interventions that suppress melanocytes and tyrosinase.