活体肝移植供肝者手术安全及术后生活质量研究进展

Systematic review of safety and quality of life of living liver donors

肝移植已成为终末期肝病的有效治疗方案,其中活体肝移植(living donor liver transplantation,LDLT)是临床肝移植(liver transplantation,LT)的重要组成部分,也是我国儿童肝移植的主要手术方式。LDLT的大力发展可相对缓解供肝短缺的现状,扩大供肝池,使等待中的受体及时获得治疗。但与此同时,LDLT也会将健康的供体暴露于手术风险之中,对其术后生活质量造成影响。因此,本文在全面回顾相关文献及结合临床实践的基础上,就活体肝移植供肝者的手术安全(死亡风险、并发症发生率及手术安全的影响因素)及术后生活质量(总体概况、躯体症状、心理状况及工作与运动)进行综述,为临床上供体的选择与决策以及供体的围手术期管理提供理论依据。

Living donor liver transplantation(LDLT)is an integral part of clinical liver transplantation(LT).It has been a major choice of pediatric LT in China's Mainland.Though LDLT may expand the donor liver pool and save life for recipients on a waiting list.Also it puts healthy donors at the risk of surgery and affect their postoperative quality-of-life.Through a literature review,donor safety(mortality&complications)and quality-of-life post-donation(physical symptoms,psychological status&employment status,etc)were discussed for providing theoretical rationales for donor selection,decision-making and postoperative nursing.